Amoy Coace Plastic Technology Co.,Ltd
Add:131 Xifu Road, Xike Industrial Park, Xiamen, Fujian, China
Contact us:Micheal li
Principle of Solubilization
Surfactant can increase the solubility of insoluble drugs, it is generally believed that because it can form in water Gel Group (Micelle) results. A pellet is a spherical body formed by a lipophilic group of surfactants (forming a very small oil droplet, a non-polar central region), and a hydrophilic group outward (a nonionic hydrophilic group extending from the surface of the oil droplets to the water in a wave-like manner). The whole gum group is non-polar inside and outside polarity. Because the micelles are tiny colloidal particles. Its dispersing system belongs to solution, which can make the insoluble drug be concealed or absorbed, and increase the dissolved amount. Because of the different permittivity of the inner and ambient solvents, the insoluble drugs interact with the micelles in different ways according to their chemical properties, so that the drug molecules disperse in the micelle.
For non-polar drugs containing benzene, toluene and other non-polar molecules of strong affinity with the solvent of the lipophilic group has a strong compatibility, solubilization of drug molecules can be drilled into the micelle inside (non-polar Central area) and surrounded by the hydrophobic base. For polar drugs, the polar dominant molecule containing P-cresol can be completely adsorbed between the hydrophilic radicals on the surface of the micelle and be dissolved. For non-polar drugs, both polar and nonpolar, such as salicylic acid, cresol, fatty acid and so on, its polar parts of the molecule (such as benzene ring) into the micelle of oil droplets (non-polar Central region), the polar part (such as phenol hydroxyl, hydroxyl) extends to the surface of the hydrophilic surfactant between the water soluble.
Related Industry Knowledge
- Compatibility functions
- Classification of compatibility
- Cyclic anhydride (MAH)
- Compatibility of classification and...
- Application compatibility
- Range of application
- Applied to the plastic coupling wit...
- Plastic compatibility
- Maleic anhydride graft polypropylene
- Compatibilizer for ldpe LDPE-g-MAH
- Compatibilizer for nylon 6
- Compatibilizer for PA6
- Toughener definition
- Impact modifier
- Additives for Plastics
- Adding method of plastic additive
- What are the common types of plasti...
- Impact Modifiers For Plastics
- Current situation of impact modifiers