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Compatibilizer for pp
Jun 22, 2017

Principle of Solubilization

Surfactant can increase the solubility of insoluble drugs, it is generally believed that because it can form in water Gel Group (Micelle) results. A pellet is a spherical body formed by a lipophilic group of surfactants (forming a very small oil droplet, a non-polar central region), and a hydrophilic group outward (a nonionic hydrophilic group extending from the surface of the oil droplets to the water in a wave-like manner). The whole gum group is non-polar inside and outside polarity. Because the micelles are tiny colloidal particles. Its dispersing system belongs to solution, which can make the insoluble drug be concealed or absorbed, and increase the dissolved amount. Because of the different permittivity of the inner and ambient solvents, the insoluble drugs interact with the micelles in different ways according to their chemical properties, so that the drug molecules disperse in the micelle.

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For non-polar drugs containing benzene, toluene and other non-polar molecules of strong affinity with the solvent of the lipophilic group has a strong compatibility, solubilization of drug molecules can be drilled into the micelle inside (non-polar Central area) and surrounded by the hydrophobic base. For polar drugs, the polar dominant molecule containing P-cresol can be completely adsorbed between the hydrophilic radicals on the surface of the micelle and be dissolved. For non-polar drugs, both polar and nonpolar, such as salicylic acid, cresol, fatty acid and so on, its polar parts of the molecule (such as benzene ring) into the micelle of oil droplets (non-polar Central region), the polar part (such as phenol hydroxyl, hydroxyl) extends to the surface of the hydrophilic surfactant between the water soluble.